Why do neutrophils stop phagocytizing and die soon after arriving at an injury site?

Study for the Penn Foster Cytology Test. Prepare with flashcards and multiple choice questions, each featuring hints and detailed explanations. Get ready for your exam!

Neutrophils are a type of white blood cell that plays a crucial role in the immune response, particularly in responding to infections and injuries. Once they arrive at the site of injury or infection, their primary function is to engulf and digest pathogens through a process known as phagocytosis.

The correct answer highlights that neutrophils can alter the pH around themselves, which contributes to their eventual death after they have completed their role in the inflammatory response. This change in pH can create an environment that is less favorable for further microbial activity but also negatively impacts the neutrophils’ survival. As they release various enzymes and reactive oxygen species (which are involved in breaking down pathogens), they also contribute to the tissue damage and alterations in the microenvironment that can lead to their own apoptosis (programmed cell death).

Neutrophils are designed to act quickly and effectively but are also limited in their lifespan as part of their biological purpose to clear infections quickly. They are highly effective but not meant to live long in tissue; their rapid death after fulfilling their function helps prevent excessive tissue damage and promotes the resolution of inflammation.

The other choices don't accurately describe the primary reason why neutrophils stop phagocytizing and die. Cons

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