Why are lymph node tissues sampled from enlarged nodes?

Sampling lymph node tissues from enlarged nodes is primarily conducted to determine the cause of the enlargement. Enlarged lymph nodes can indicate a range of underlying issues, such as infections, inflammatory conditions, or malignancies. By analyzing the cellular makeup and histopathology of the lymph node, clinicians can identify whether the enlargement is due to a benign condition like an infection or a more serious issue such as cancer. This diagnostic process is crucial for deciding on appropriate treatment plans and interventions for the patient.

In contrast, while assessing blood supply, investigating genetic diseases, or examining lymphatic drainage might provide relevant information in certain contexts, these factors do not directly address the immediate need for understanding the specific reasons behind lymph node enlargement. Therefore, they are not the primary purpose of tissue sampling in this scenario.