Which type of cell is typically rare in lymphoma compared to normal lymphatic tissue?

In the context of lymphoma, plasma cells are typically rare compared to normal lymphatic tissue. Lymphoma primarily arises from the proliferation of lymphoid tissue, which includes lymphocytes such as B cells and T cells. In normal lymphatic tissue, plasma cells are present but are relatively few in number since they are the fully differentiated form of B lymphocytes, responsible for antibody production. In lymphoma, particularly in certain types like Hodgkin lymphoma and some non-Hodgkin lymphomas, you see an altered composition where there is an increase in malignant lymphocytes and a decrease or absence of normal plasma cells.

The presence of plasma cells would suggest a different pathological process, such as multiple myeloma, where these cells are predominant due to their role in producing excessive antibodies. Therefore, understanding the typical cellular makeup of lymphatic tissues helps clarify why plasma cells are rare in the setting of lymphoma.