Which of the following is NOT a nuclear criterion associated with malignant neoplasia?

The correct answer identifies "rounded nuclei" as not being a nuclear criterion typically associated with malignant neoplasia. In the context of malignancy, certain nuclear features are indicative of abnormal cell behavior and growth patterns.

Increased nucleus size is a well-documented characteristic of malignant neoplasia, often reflecting greater metabolic activity and an increased propensity for uncontrolled growth. Similarly, cells exhibiting multiple nuclei—known as multinucleation—are also a clear indicator of malignancy, as this can result from abnormal cell division or a failure in cytokinesis. Angled nuclei, or irregular shapes, suggest abnormal chromatin organization and cell stress, which can be associated with cancerous transformations.

Rounded nuclei, however, are not inherently indicative of malignancy. While nuclear shape can vary in different cell types and conditions, rounded nuclei can also be observed in benign processes. Therefore, this option stands out as it does not fit into the established criteria for malignant neoplasia, making it the correct choice in this context. Understanding these distinctions is critical for accurately identifying and diagnosing cancerous versus non-cancerous cell changes.