Where are the most cells likely to be found when using a combination technique on a low cellularity sample?

When using a combination technique on a low cellularity sample, the most cells are likely to be found in the untouched center of the slide. This is because the combination technique typically involves spreading the sample to create a monolayer of cells.

In a low cellularity sample, cells may not be evenly distributed, and the process can lead to a situation where many cells accumulate in the area that has not been disturbed by the spreading action. The center of the slide tends to retain cells better due to the way the sample is placed and spread, allowing for a higher concentration in this region.

Understanding the distribution of cells in cytological preparations is crucial, as it influences the accuracy of diagnoses and the quality of samples collected for analysis. Knowing where to look for cells within the slide can significantly enhance the effectiveness of a cytology examination.