What role do macrophages play in inflammation?

Macrophages play a crucial role in inflammation primarily through their involvement in the repair of tissues after injury or infection. When tissue damage occurs, macrophages are activated and migrate to the site of inflammation. Their functions include phagocytosing pathogens, dead cells, and debris, thus clearing the area to facilitate healing.

Additionally, macrophages secrete various cytokines and growth factors that recruit other immune cells to the area, promoting a coordinated inflammatory response and supporting tissue repair processes. By resolving inflammation and aiding in the regeneration of damaged tissues, they help restore homeostasis.

While other choices mention processes related to inflammation, such as blood clotting and histamine release, those functions are carried out by different types of cells. For example, platelets are primarily responsible for starting blood clotting, mast cells release histamine to initiate inflammation, and connective tissue cells provide structural support. Thus, the choice highlighting macrophages’ role in tissue repair aligns accurately with their primary functions in the inflammatory response.