What does the evaluation of cellular architecture in histopathology require that cytology does not?

The evaluation of cellular architecture in histopathology focuses on understanding the organization and structure of cells within a tissue context. This requires analyzing not just individual cells but also the relationship and arrangement of neighboring cells and their structural organization. Histopathology involves examining tissue samples, which allows for a comprehensive view of cellular architecture, including cell type, structure, and their spatial relationships.

In contrast, cytology primarily emphasizes the examination of individual cells obtained from various specimens (such as aspirates or smears) without the extensive context of their surrounding tissue architecture. While cytology can provide valuable information about cellular characteristics and potential abnormalities, it does not provide insight into how cells interact with one another or their environments in a tissue setting. Therefore, the analysis of neighboring cells and structures is a critical component of histopathology that distinguishes it from cytology.